Abstract: The topic of the research is the artistic image of Macau in the process of interaction between Eastern and Western cultures. The object of the research is the stages of formation of this image, starting with traditional art, modern artistic image and development of public artistic practices. The study of the evolution of the artistic image of Macau through the analysis of works of Chinese and Western artists allows us to demonstrate how the interaction of cultures influences the formation of a unique artistic image of the region. The methodological basis of the work was the historical-biographical and comparative-historical approaches. The historical-biographical method allows us to focus on the influence of the biographical aspects of the artists on their work. The main conclusions of the study are that the artistic image of Macau is the result of a unique process of cultural synthesis, in which Eastern and Western traditions mutually enrich each other. This process, which began in the Ming Dynasty, continued through Portuguese colonization and remains relevant to this day, demonstrating the importance of cultural interaction in the creation of outstanding works of art. Macau has had a significant influence on the formation of the style of such artists as George Chinnery and Augustin Bolger. The novelty of this study lies in its use of a comparative historical method, which, combined with biographical analysis of artists such as Chinnery, demonstrates how their personal experiences and cross-cultural interactions are reflected in their works, shaping the unique artistic identity of Macau. The results obtained contribute to a deeper understanding of cultural processes and can be used to develop strategies for the preservation and promotion of the region's unique cultural heritage.