Abstract: The object of this research is the motivational and semantic relations of the individual. The subject of the research is the motivational and semantic relations of employees with different professional affiliations and specifics of performing functional duties. The purpose of the research is to study the structure of motivational and semantic relations of a person and to identify patterns of influence of professional affiliation and functional duties. The methodological basis for writing the article is the research of domestic and foreign scientists. Theoretical (comparative analysis) and empirical (interview, questionnaire) research methods were used in the study. The orientation of motivational and semantic relations of a person does not depend on the professional affiliation and the specifics of the performance of functional duties. Since the motivational and semantic relations of a person in professional activity are characterized by the presence of motivation based on the personal meaning, which motivates a person to activity and depend on the psychological state of a person who is in certain life circumstances. Motivational and semantic relations of a person are based on motivational and semantic processes that accompany and support a person throughout his or her working life. The aim of the work is to establish the regularities of the influence of professional affiliation and the specifics of functional duties on the motivational and semantic relations of employees to professional activities. In order to increase the efficiency of professional activities and improve the motivation of employees to the heads of organizations, the authors give practical recommendations for improving psychological support in organizations.