Abstract: The subject of the research is a range of economic interrelations in regional economics in the sphere of economic security. The object of the research includes industrial and agro-industrial sectors of regional economics. The author considers the advantages of cluster integration for the solution of the most important issues of economic and biosafety of a region. Special attention is paid to the analysis of the applied methods in terms of the existing situation on the international scene and to the consideration of these problems in Moscow region. The author uses the methods of abstraction, deduction, induction, logics, and the method of economic statistics. The author enumerates the government interests which are realized by means of strengthening of economic clusters in the regions. The author assesses the positive and negative sides of integration within the clusters. The author attempts to predict the prospect of the future development of industrial and agro-industrial clusters of regional economics.