Abstract: The subject field of this research is the educational organization and its place within the regional space of innovations creation. Based on this, the article determines the key directions and barriers of innovation development of a state and its regions, as well as the role and importance of the professional potential for ensuring the necessary level of innovation activity of the enterprises. On the precise example the author examines the forms and results on interaction between the university, industrial enterprises, and region, as well as defines the vectors of increasing efficiency of collaboration of all parties interested in innovation development. The scientific novelty of this work consists in reviewing the region’s innovation potential and determination of the role of educational organizations in its application. Conclusions made during the course of this research identify the actual directions and efficient tools of managing interaction between the key actors of innovation space. The following can be considered as such: the need for renewing the scientific research and laboratorial base of a university in accordance with the requirements of the enterprises’ innovation developments; expansions of the scientific research topics for overcoming the limited segment specificity; as well as search for the ways to balance demand and candidate pool on the regional job market. s