Abstract: The subject of this research is the approaches of U. S. “think tanks” to the problem of Britain leaving the European Union. Special attention is paid to analysis of the centers loyal to the policy of the Republican and Democratic Parties of the United States regarding one of the fundamental disintegration problems in Europe. The authors examine such aspects of the topic as forecast of Britain’s split from EU, consequences of Brexit for the United States and American-British relations, future of the trade and economic cooperation and question of ensuring security, recommendations and modeling of the most favorable scenario of Brexit from the perspective of approaches of the U. S. analytical centers. The agenda-setting theory is selected as theoretical framework to confirm the impact of materials of the U. S. analytical centers, which share the views of the Republican and Democratic Parties, upon the stance of one or another presidential administration on Brexit. The conclusion is made that Brexit causes concern of the American political and analytical structures, substantiated by its influence on the development of American-British relations that play the key role for the interests of the United States in Europe. The authors’ special contribution consists in determination of commitment of the selected for consideration analytical centers to the two major U. S. parties. The scientific novelty lies in tracing the difference between the approaches towards conducting foreign policy by analytical centers that support the Democratic and Republican Parties of the United States. Substantial differences of the approaches prove that despite the officially declared independence, the activity of the analytical centers is associated with the activity of political structures.